Physiologically based pharmacokinetic modeling for umbelliferone in rats and humans: impact of extrahepatic phase II metabolism and hepatic/gut first-pass extraction on oral bioavailability and systemic disposition
Ji-Su Kong, Seong‐Wook Seo, Tae Young Kim, Hyung Ryong Moon, Jin‐Wook Yoo, Min‐Soo Kim, Hwayoung Yun, Seonghwan Hwang, Ee Taek Hwang, Yunjin Jung, In‐Soo Yoon
IF 5.1 (2025) Journal of Pharmaceutical Investigation
키워드
Physiologically based pharmacokinetic modellingUmbelliferonePharmacokineticsBioavailabilityIn vivoDrug metabolismIn silicoOral administration