신규한 류코트리엔 B4 수용체 저해제 및 이의 용도
Novel compound as a leukotriene B4 receptor inhibitor and use thereof
특허 요약
본 발명은 신규한 류코트리엔 B4 수용체 저해제로서 N-페닐벤조옥사졸로-2-아민 및 N-페닐옥사졸로피리딘-2-아민 유도체 및 이의 용도에 관한 것이다.
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  1. 5-플루오로-N-(2-메톡시-4-니트로페닐)벤조[d]옥사졸-2-아민(5-fluoro-N-(2-methoxy-4-nitrophenyl)benzo[d]oxazol-2-amine),6. 6-플루오로-N-(2-메톡시-4-니트로페닐)벤조[d]옥사졸-2-아민(6-fluoro-N-(2-methoxy-4-nitrophenyl)benzo[d]oxazol-2-amine),10. 6-클로로-N-(2-메톡시-4-니트로페닐)벤조[d]옥사졸-2-아민(6-chloro-N-(2-methoxy-4-nitrophenyl)benzo[d]oxazol-2-amine),11. 5,7-디클로로-N-(2-니트로페닐)벤조[d]옥사졸-2-아민(5,7-dichloro-N-(2-nitrophenyl)benzo[d]oxazol-2-amine),12. 5,7-디클로로-N-(3-니트로페닐)벤조[d]옥사졸-2-아민(5,7-dichloro-N-(3-nitrophenyl)benzo[d]oxazol-2-amine),13. 5,7-디클로로-N-(4-니트로페닐)벤조[d]옥사졸-2-아민(5,7-dichloro-N-(4-nitrophenyl)benzo[d]oxazol-2-amine),14. 5,7-디클로로-N-(2-메톡시-4-니트로페닐)벤조[d]옥사졸-2-아민(5,7-dichloro-N-(2-methoxy-4-nitrophenyl)benzo[d]oxazol-2-amine),15. 5-클로로-N-(2-메톡시-4-니트로페닐)-6-니트로페닐로벤조[d]옥사졸-2-아민(5-chloro-N-(2-methoxy-4-nitrophenyl)-6-nitrobenzo[d]oxazol-2-amine),16. 7-클로로-N-(2-메톡시-4-니트로페닐)-5-니트로페닐로벤조[d]옥사졸-2-아민(7-chloro-N-(2-methoxy-4-nitrophenyl)-5-nitrobenzo[d]oxazol-2-amine),17. 5,7-디클로로-6-에틸-N-(2-메톡시-4-니트로페닐)벤조[d]옥사졸-2-아민(5,7-dichloro-6-ethyl-N-(2-methoxy-4-nitrophenyl)benzo[d]oxazol-2-amine),18. 5-tert-부틸-N-(2-메톡시-4-니트로페닐)벤조[d]옥사졸-2-아민(5-tert-butyl-N-(2-methoxy-4-nitrophenyl)benzo[d]oxazol-2-amine),19. 5-메톡시-N-(2-메톡시-4-니트로페닐)벤조[d]옥사졸-2-아민(5-methoxy-N-(2-methoxy-4-nitrophenyl)benzo[d]oxazol-2-amine),20. 6-브로모-N-(2-메톡시-4-니트로페닐)옥사졸로[4,5-b]피리딘-2-아민(6-bromo-N-(2-methoxy-4-nitrophenyl)oxazolo[4,5-b]pyridin-2-amine),23. N1-(5-플루오로벤조[d]옥사졸-2-일)-2-메톡시벤젠-1,4-디아민(N1-(5-fluorobenzo[d]oxazol-2-yl)-2-methoxybenzene-1,4-diamine),26. N1-(6-플루오로벤조[d]옥사졸-2-일)-2-메톡시벤젠-1,4-디아민(N1-(6-fluorobenzo[d]oxazol-2-yl)-2-methoxybenzene-1,4-diamine),30. N1-(6-클로로벤조[d]옥사졸-2-일)-2-메톡시벤젠-1,4-디아민(N1-(6-chlorobenzo[d]oxazol-2-yl)-2-methoxybenzene-1,4-diamine),31. N1-(5,7-디클로로벤조[d]옥사졸-2-일)벤젠-1,2-디아민(N1-(5,7-dichlorobenzo[d]oxazol-2-yl)benzene-1,2-diamine),32. N1-(5,7-디클로로벤조[d]옥사졸-2-일)벤젠-1,3-디아민(N1-(5,7-dichlorobenzo[d]oxazol-2-yl)benzene-1,3-diamine),33. N1-(5,7-디클로로벤조[d]옥사졸-2-일)벤젠-1,4-디아민(N1-(5,7-dichlorobenzo[d]oxazol-2-yl)benzene-1,4-diamine),34. N1-(5,7-디클로로벤조[d]옥사졸-2-일)-2-메톡시벤젠-1,4-디아민(N1-(5,7-dichlorobenzo[d]oxazol-2-yl)-2-methoxybenzene-1,4-diamine),35. N1-(5-tert-부틸벤조[d]옥사졸-2-일)-2-메톡시벤젠-1,4-디아민(N1-(5-tert-butylbenzo[d]oxazol-2-yl)-2-methoxybenzene-1,4-diamine),36. 2-메톡시-N1-(5-메톡시벤조[d]옥사졸-2-일)벤젠-1,4-디아민(2-methoxy-N1-(5-methoxybenzo[d]oxazol-2-yl)benzene-1,4-diamine),37. 2-(6-클로로벤조[d]옥사졸-2-일아미노)-5-니트로페닐로페놀(2-(6-chlorobenzo[d]oxazol-2-ylamino)-5-nitrophenol),38. 2-(2-(5-플루오로벤조[d]옥사졸-2-일아미노)페닐아미노)-2-옥소에틸 아세테이트(2-(2-(5-fluorobenzo[d]oxazol-2-ylamino)phenylamino)-2-oxoethyl acetate),39. 2-(3-(5-플루오로벤조[d]옥사졸-2-일아미노)페닐아미노)-2-옥소에틸 아세테이트(2-(3-(5-fluorobenzo[d]oxazol-2-ylamino)phenylamino)-2-oxoethyl acetate),40. 2-(4-(5-플루오로벤조[d]옥사졸-2-일아미노)-3-메톡시페닐아미노)-2-옥소에틸 아세테이트(2-(4-(5-fluorobenzo[d]oxazol-2-ylamino)-3-methoxyphenylamino)-2-oxoethyl acetate),41. 2-(3-(6-플루오로벤조[d]옥사졸-2-일아미노)페닐아미노)-2-옥소에틸 아세테이트(2-(3-(6-fluorobenzo[d]oxazol-2-ylamino)phenylamino)-2-oxoethyl acetate),42. 2-(4-(6-플루오로벤조[d]옥사졸-2-일아미노)페닐아미노)-2-옥소에틸 아세테이트(2-(4-(6-fluorobenzo[d]oxazol-2-ylamino)phenylamino)-2-oxoethyl acetate),43. 2-(4-(6-플루오로벤조[d]옥사졸-2-일아미노)-3-메톡시페닐아미노)-2-옥소에틸 아세테이트(2-(4-(6-fluorobenzo[d]oxazol-2-ylamino)-3-methoxyphenylamino)-2-oxoethyl acetate),44. 2-(2-(5-클로로벤조[d]옥사졸-2-일아미노)페닐아미노)-2-옥소에틸 아세테이트(2-(2-(5-chlorobenzo[d]oxazol-2-ylamino)phenylamino)-2-oxoethyl acetate),45. 2-(4-(6-클로로벤조[d]옥사졸-2-일아미노)페닐아미노)-2-옥소에틸 아세테이트(2-(4-(6-chlorobenzo[d]oxazol-2-ylamino)phenylamino)-2-oxoethyl acetate),46. 2-(3-(6-클로로벤조[d]옥사졸-2-일아미노)페닐아미노)-2-옥소에틸 아세테이트(2-(3-(6-chlorobenzo[d]oxazol-2-ylamino)phenylamino)-2-oxoethyl acetate),47. 2-(2-(5,7-디클로로벤조[d]옥사졸-2-일아미노)페닐아미노)-2-옥소에틸 아세테이트(2-(2-(5,7-dichlorobenzo[d]oxazol-2-ylamino)phenylamino)-2-oxoethyl acetate),48. 2-(3-(5,7-디클로로벤조[d]옥사졸-2-일아미노)페닐아미노)-2-옥소에틸 아세테이트(2-(3-(5,7-dichlorobenzo[d]oxazol-2-ylamino)phenylamino)-2-oxoethyl acetate),49. 2-(4-(5,7-디클로로벤조[d]옥사졸-2-일아미노)페닐아미노)-2-옥소에틸 아세테이트(2-(4-(5,7-dichlorobenzo[d]oxazol-2-ylamino)phenylamino)-2-oxoethyl acetate),50. 2-(4-(5,7-디클로로벤조[d]옥사졸-2-일아미노)-3-메톡시페닐아미노)-2-옥소에틸 아세테이트(2-(4-(5,7-dichlorobenzo[d]oxazol-2-ylamino)-3-methoxyphenylamino)-2-oxoethyl acetate),51. N-(2-(5-플루오로벤조[d]옥사졸-2-일아미노)페닐)-2-히드록시아세타미드(N-(2-(5-fluorobenzo[d]oxazol-2-ylamino)phenyl)-2-hydroxyacetamide),52. N-(3-(5-플루오로벤조[d]옥사졸-2-일아미노)페닐)-2-히드록시아세타미드(N-(3-(5-fluorobenzo[d]oxazol-2-ylamino)phenyl)-2-hydroxyacetamide),53. N-(4-(5-플루오로벤조[d]옥사졸-2-일아미노)-3-메톡시페닐)-2-히드록시아세타미드(N-(4-(5-fluorobenzo[d]oxazol-2-ylamino)-3-methoxyphenyl)-2-hydroxyacetamide),54. N-(3-(6-플루오로벤조[d]옥사졸-2-일아미노)페닐)-2-히드록시아세타미드(N-(3-(6-fluorobenzo[d]oxazol-2-ylamino)phenyl)-2-hydroxyacetamide),55. N-(4-(6-플루오로벤조[d]옥사졸-2-일아미노)페닐)-2-히드록시아세타미드(N-(4-(6-fluorobenzo[d]oxazol-2-ylamino)phenyl)-2-hydroxyacetamide),56. N-(4-(6-플루오로벤조[d]옥사졸-2-일아미노)-3-메톡시페닐)-2-히드록시아세타미드(N-(4-(6-fluorobenzo[d]oxazol-2-ylamino)-3-methoxyphenyl)-2-hydroxyacetamide),57. N-(2-(5-클로로벤조[d]옥사졸-2-일아미노)페닐)-2-히드록시아세타미드(N-(2-(5-chlorobenzo[d]oxazol-2-ylamino)phenyl)-2-hydroxyacetamide),58. N-(3-(6-클로로벤조[d]옥사졸-2-일아미노)페닐)-2-히드록시아세타미드(N-(3-(6-chlorobenzo[d]oxazol-2-ylamino)phenyl)-2-hydroxyacetamide),59. N-(2-(5,7-디클로로벤조[d]옥사졸-2-일아미노)페닐)-2-히드록시아세타미드(N-(2-(5,7-dichlorobenzo[d]oxazol-2-ylamino)phenyl)-2-hydroxyacetamide),60. N-(3-(5,7-디클로로벤조[d]옥사졸-2-일아미노)페닐)-2-히드록시아세타미드(N-(3-(5,7-dichlorobenzo[d]oxazol-2-ylamino)phenyl)-2-hydroxyacetamide),61. N-(4-(5,7-디클로로벤조[d]옥사졸-2-일아미노)페닐)-2-히드록시아세타미드(N-(4-(5,7-dichlorobenzo[d]oxazol-2-ylamino)phenyl)-2-hydroxyacetamide),62. N-(4-(5,7-디클로로벤조[d]옥사졸-2-일아미노)-3-메톡시페닐)-2-히드록시아세타미드(N-(4-(5,7-dichlorobenzo[d]oxazol-2-ylamino)-3-methoxyphenyl)-2-hydroxyacetamide),65. tert-부틸 4-(4-(5-tert-부틸벤조[d]옥사졸-2-일아미노)-3-메톡시페닐아미노)-4-옥소부틸카바메이트(tert-butyl 4-(4-(5-tert-butylbenzo[d]oxazol-2-ylamino)-3-methoxyphenylamino)-4-oxobutylcarbamate),66. tert-부틸 4-(3-메톡시-4-(5-메톡시벤조[d]옥사졸-2-일아미노)페닐아미노)-4-옥소부틸카바메이트(tert-butyl 4-(3-methoxy-4-(5-methoxybenzo[d]oxazol-2-ylamino)phenylamino)-4-oxobutylcarbamate),67. 4-아미노-N-(3-메톡시-4-(5-메톡시벤조[d]옥사졸-2-일아미노)페닐)부탄아미드(4-amino-N-(3-methoxy-4-(5-methoxybenzo[d]oxazol-2-ylamino)phenyl)butanamide) 또는 이의 약학적으로 허용 가능한 염.
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제4항의 화합물, 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는, LTB4 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물로서,상기 LTB4 수용체 활성 관련 질환은 염증성 질환, 심혈관 질환 또는 암질환인 것인, 약학적 조성물.

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제13항에 있어서,BLT2의 활성화에 의한 세포의 이동, 침윤 또는 둘 모두의 증가를 억제하는 효과를 발휘하는 것인, 약학적 조성물.

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