Wound dehiscence after coronary artery bypass grafting (CABG) with bilateral internal mammary artery grafts presents substantial clinical challenges, particularly among patients with multiple comorbidities. Traditional reconstruction methods are often unsuccessful in repairing complex anterior chest wall defects. We present a case of a 45-year-old female with hypertension, diabetes, and end-stage renal disease who developed sternal dehiscence after CABG. Conventional methods were inadequate, warranting the use of an omental flap combined with a split-thickness skin graft (STSG). The omental flap provided effective defect coverage and enhanced wound healing through its rich vascular supply. Notwithstanding the need for minor secondary healing, this approach was successful. The case demonstrates that the omental flap combined with STSG offers a feasible approach for complex chest wall defects and highlights the importance of preventing complications such as herniation.