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인용수 10
·2019
Kinetic Resolution of Racemic Aldehydes through Asymmetric Allenoate γ-Addition: Synthesis of (+)-Xylogiblactone A
Saehansaem Park, Gyungah Pak, Changhwa Oh, Jieun Lee, Jimin Kim, Chan‐Mo Yu
IF 5Organic Letters
초록

A synthesis of (+)-xylogiblactone A has been achieved from <i>t</i>-butyl 2-methylbuta-2,3-dienoate in a linear three-step sequence. The key elements of the synthesis include a kinetic resolution of racemic 2-silyoxyaldehyde through the allenoate γ-addition to yield the γ-adduct as a single isomer and the subsequent gold catalysis to form the butenolide core. For a general method, the kinetic resolution of several racemic 2-silyloxyaldehydes is also performed to provide products in high levels of stereoselectivity with unusual <i>anti</i>-Felkin-Anh addition fashion.

키워드
Kinetic resolutionChemistryStereoselectivityYield (engineering)Enantioselective synthesisAdductButenolideStereochemistryCatalysisResolution (logic)
타입
article
IF / 인용수
5 / 10
게재 연도
2019