김희진 교수 연구실
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·인용수 1
·2025
Mutations in gyrA and gyrB among drug-resistant Mycobacterium tuberculosis isolates in South Korea
Seungmo Kim, Hwi Jun Kim, Ryeun Heo, Hyeon-Su Kim, Jeongmin Song, Cheon-Tae Kim, Heejin Kim, Soul-hee Kim, Jeong-hui Gwon, Gicheon Bae, Shin‐Wook Kang, Kwang-Hyuk Seok, Eunseon Kim, Di Han, Mi-so Kim, Hyeon-Ju Lee, Seonmi Shin, Arim Song, Gyeong In Lee, Seung‐Heon Lee, Hye-Jin Kim, Orena Beatrice, Juliet N. Babirye, Ocung Guido, Mary Akumu, Hee Joo Lee
Infection Genetics and Evolution
초록
This study confirms gyrA mutations, especially D94G, as primary determinants of FLQ resistance in drug-resistant TB (including MDR-TB) in South Korea. gyrB mutations may also influence resistance. Combining gDST with phenotypic methods may improve resistance profiling.
키워드
Mycobacterium tuberculosisMutationTuberculosisPhenotypeStrain (injury)GenotypeResistance (ecology)DNA gyrase