Abstract Hitherto marginalized in the extant innovation studies is the role of intermediaries in innovation ecosystems, which require greater coordination and orchestration between manifold organizations. We conduct qualitative research on the Precision Engineering Centre of Innovation to understand how this government-affiliated intermediary in Singapore takes the initiative in shaping an innovation ecosystem through which local/foreign precision engineering firms, government agencies, and multinational corporations harmoniously co-develop advanced manufacturing capabilities. By analyzing the qualitative data through the theoretical lenses of innovation ecosystem and intermediary, our findings reveal that intermediaries nurture ecosystems in four major steps: (1) developing the ecosystem vision, (2) forming the ecosystem community, (3) orchestrating the ecosystem resources, and (4) materializing the new value proposition. Based on this process model, the implications for innovation intermediary research, innovation ecosystem studies, and innovation policy are discussed.