In this study, a fuel cell system for future defense unmanned vehicles was designed and validated. A Co/Al2O3-Ni foam catalyst for NaBH4 hydrolysis was characterized using several analytical methods. A NaBH4 hydrogen generation system with the Co/Al2O3-Ni foam catalyst continuously generated hydrogen at elevated reaction temperatures. The fuel cell system with the NaBH4 hydrogen generation system was designed and tested. The performance of the fuel cell system was comparable to that of the fuel cell system using pure hydrogen. Therefore, the fuel cell system with the NaBH4 hydrogen generation system is a suitable power source for future defense unmanned vehicles owing to its easy refueling and simple system.