Abstract To address the computational challenges of Model Predictive Control (MPC), recent research has studied using imitation learning to approximate MPC with a computationally efficient Deep Neural Network (DNN). However, this introduces a common issue in learning-based control, the simulation-to-reality (sim-to-real) gap. Inspired by Robust Tube MPC, this study proposes a new control framework that addresses this issue from a control perspective. The framework ensures the DNN operates in the same environment as the source domain, addressing the sim-to-real gap with great data collection efficiency. Moreover, an input refinement governor is introduced to address the DNN’s inability to adapt to variations in model parameters, enabling the system to satisfy MPC constraints more robustly under parameter-changing conditions. The proposed framework was validated through two case studies: cart-pole control and vehicle collision avoidance control, which analyzed the principles of the proposed framework in detail and demonstrated its application to a vehicle control case.