백승훈 교수 연구실
article|
hybrid
·인용수 151
·2020
Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis
Eun Hee Koh, Ji Eun Yoon, Myoung Seok Ko, Jaechan Leem, Ji Young Yun, Chung Hwan Hong, Yun Kyung Cho, Seung Eun Lee, Jung Eun Jang, Ji Yeon Baek, Hyun Ju Yoo, Su Jung Kim, Chang Ohk Sung, Joon Seo Lim, Won‐Il Jeong, Sung Hoon Back, In‐Jeoung Baek, Sandra Torres, Estel Solsona‐Vilarrasa, Laura Conde de la Rosa, Carmen García‐Ruiz, Ariel E. Feldstein, José C. Fernández‐Checa, Ki‐Up Lee
IF 25.8Gut
초록
SMS1 mediates hepatocyte pyroptosis through a novel DAG-PKCδ-NLRC4 axis and holds promise as a therapeutic target for NASH.
키워드
PyroptosisHepatocyteSteatohepatitisInflammasomeCell biologyDiacylglycerol kinaseLiver injuryChemistryBiologyFatty liver