Purpose: To compare the clinical outcomes of enhanced monofocal IOL (Eyhance) and monofocal IOL (TECNIS) implantation in cataract patients whose target refraction is myopia. Methods: This is a retrospective chart review for patients who underwent cataract surgery and whose target refraction is myopia (-3 D). A total of 68 eyes were enrolled (34 patients enrolled: enhanced monofocal (Group 1) = 32 eyes, monofocal (Group 2) = 36 eyes; bilateral IOL implantation in each patient). For the primary endpoint, uncorrected and corrected near (UNVA and CNVA), intermediate (UIVA and CIVA), and distant (UDVA and CDVA) visual acuities; manifest refraction spherical equivalent (MRSE); and satisfaction score were evaluated before and 3 months after surgery. Results: < 0.05), whereas contrast sensitivity did not differ significantly between the groups. Conclusion: Enhanced monofocal IOL with a myopic target showed better corrected intermediate vision and uncorrected very near vision at 20 cm compared with monofocal IOL. Overall satisfaction with enhanced monofocal IOL is also higher than with monofocal IOL.