Aloe vera, a medicinal herb with a lengthy history in traditional and folk medicine, is widely used today as a common ingredient in various healthcare and beauty products.Extensive research has been conducted to verify its therapeutic effectiveness, understand its mechanisms, and identify the active components responsible for its properties.The plant has been found to possess numerous biological properties, including immune system regulation, anti-inflammatory effects, promotion of wound healing, potential anticancer activity, antiviral properties, management of diabetes, and protection against radiation.While the polysaccharides present in the inner gel, particularly acemannan, have been credited for many of therapeutic effects of A. vera, other constituents such as lectins, alkaloids, anthraquinones, anthrones, chromones, coumarins, and polyphenols also contribute to its diverse and numerous benefits.In this review, we focus on acemannan, a well-studied polysaccharide extracted from A. vera gel, while highlighting the recently discovered effects and applications of this remarkable plant.