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·2025
Investigation of the Relationship Between Electrical Conductivity, Diffusivity, and Tissue Volume in the Aging Brain
Geon‐Ho Jahng, Mun Bae Lee, Hak Young Rhee, Soonchan Park, Chang‐Woo Ryu
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
초록

Motivation: This study provides novel insights into the intricate relationships between brain electrical conductivity, diffusivity, and tissue volume in elderly individuals. Goal(s): To explore the relationships between electrical conductivity, diffusivity, and brain tissue volume in the aging brain. Approach: With 77 patients, brain MREPT and DTI were employed to calculate high-frequency conductivity (HFC) and separate it into extra-neurite (EC) and intra-neurite (IC) conductivities. Results: Multiple regression revealed a positive association of both HFC and EC with MD, RD, and axial diffusivity (AxD) in the hippocampus and insula. IC correlated positively with intra-neurite diffusivity (ID) in the amygdala, thalamus, and insula. Impact: This research underscores the importance of distinguishing between conductivity and diffusion changes when interpreting clinical MREPT data.

키워드
Brain tissueThermal diffusivityBrain sizeVolume (thermodynamics)DiffusionHippocampusBrain aging
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2025

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