최은상 교수 연구실
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·인용수 9
·2022
Phosphorylation of GluA1-Ser831 by CaMKII Activation in the Caudate and Putamen Is Required for Behavioral Sensitization After Challenge Nicotine in Rats
Sunghyun Kim, Sumin Sohn, Eun Sang Choe
IF 4.8The International Journal of Neuropsychopharmacology
초록
These findings suggest that the GluA1-Ser831 phosphorylation in the MSNs of the CPu is required for the challenge nicotine-induced behavioral sensitization in rats. CaMKII activation linked to mGluR5 and NMDA receptors, but not to D1R, is essential for inducing the CaMKII-Ser831 interaction.
키워드
Medium spiny neuronNicotineAMPA receptorPharmacologyMetabotropic glutamate receptor 5ChemistrySensitizationMetabotropic glutamate receptor 1NMDA receptorGlutamate receptor