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·인용수 58
·2017
Implantable batteryless device for on-demand and pulsatile insulin administration
Seung Ho Lee, Young Bin Lee, Byung Hwi Kim, Chul Lee, Young Min Cho, Se-Na Kim, Chun Gwon Park, Yong-Chan Cho, Young Bin Choy
IF 15.7Nature Communications
초록

Many implantable systems have been designed for long-term, pulsatile delivery of insulin, but the lifetime of these devices is limited by the need for battery replacement and consequent replacement surgery. Here we propose a batteryless, fully implantable insulin pump that can be actuated by a magnetic field. The pump is prepared by simple-assembly of magnets and constituent units and comprises a drug reservoir and actuator equipped with a plunger and barrel, each assembled with a magnet. The plunger moves to noninvasively infuse insulin only when a magnetic field is applied on the exterior surface of the body. Here we show that the dose is easily controlled by varying the number of magnet applications. Also, pump implantation in diabetic rats results in profiles of insulin concentration and decreased blood glucose levels similar to those observed in rats treated with conventional subcutaneous insulin injections.

키워드
PlungerPulsatile flowInsulinMagnetBiomedical engineeringMaterials scienceInsulin deliveryMicrosphereMicrosystemMedicine
타입
article
IF / 인용수
15.7 / 58
게재 연도
2017