이정모 교수 연구실
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·인용수 17
·2019
Therapeutic effects of the novel Leucyl-tRNA synthetase inhibitor BC-LI-0186 in non-small cell lung cancer
Eun Young Kim, Jin Gu Lee, Jung Mo Lee, Arum Kim, Hee Chan Yoo, Kibum Kim, Minji Lee, Chulho Lee, Gyoonhee Han, Jung Min Han, Yoon Soo Chang
IF 6.852Therapeutic Advances in Medical Oncology
초록
BC-LI-0186 inhibits the noncanonical mTORC1-activating function of LRS. These results provide a new therapeutic strategy for NSCLC and warrant future clinical development by targeting LRS.
키워드
mTORC1Cancer researchP70-S6 Kinase 1Molecular biologyPhosphorylationBiologyChemistryCell biologyProtein kinase B