박세호 교수 연구실
article|
bronze
·인용수 68
·2012
Protective role of V-set and immunoglobulin domain-containing 4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liver T- and natural killer T-cells
Keun‐Ok Jung, Miseon Kang, Cheol Park, Yung Hyun Choi, Youkyoung Jeon, Se‐Ho Park, Su-Kil Seo, Dan Jin, Inhak Choi
IF 15.8Hepatology
초록
Collectively, our results suggest that VSIG4(+) KCs play a critical role in the induction and maintenance of liver T- and NKT-cell tolerance, and that modulation of the VSIG4 pathway using a VSIG4.Ig fusion protein may provide useful immunological therapies against immune-mediated liver injury including autoimmune hepatitis.
키워드
BiologyNatural killer T cellImmune systemImmune toleranceImmunologyAdoptive cell transferT cellCell biologyCancer research