민주홍 교수 연구실
article|
gold
·인용수 5
·2025
Beyond blood-brain barrier disruption and molecular weight: compartmental kinetics of S100B and NSE for neurological prognostication after cardiac arrest
Soyoung Jeon, Changshin Kang, Yenho You, Jung Soo Park, Ju‐Hong Min, Wonjoon Jeong, Hyewon Ryu, Ji‐Young Choi, Byung Kook Lee
Critical Care
초록
Serum NSE levels closely reflect the degree of BBB disruption and CSF levels, while S100B exhibits a transient early-phase profile, with decreased serum detectability over time, even in the presence of sustained CSF elevation or severe BBB disruption. These findings highlight the importance of interpreting biomarker kinetics across compartments and timepoints rather than relying on molecular weight or BBB status alone.
키워드
MedicineEnolaseCerebrospinal fluidBiomarkerInternal medicineAlbuminGastroenterologyConfidence intervalImmunohistochemistry