최동규 교수 연구실
article|
인용수 0
·2025
Down-regulation of HSPA9 reduces tyrosine hydroxylase-positive neurons in mouse substantia nigra and induces Parkinson’s disease-like motor impairments
Hyejin Hyung, Soyoung Jang, Siyong Kim, Ji‐Eun Bae, Ji Yeong Park, Su‐Geun Lim, Jiwon Ko, Soyeon Jang, Joon Bum Kim, Hee Young Chae, Song Park, Junkoo Yi, Dong Kyu Choi, Myoung Ok Kim, Hyun‐Shik Lee, Dong‐Hyung Cho, Zae Young Ryoo
IF 3.2Animal Cells and Systems
초록
mice further exacerbated the loss of dopaminergic neurons, aggravated motor impairments, and enhanced activation of apoptosis effector caspase-3. These results suggest that down-regulation of HSPA9 may contribute to the development and progression of PD, potentially offering a new therapeutic strategy for PD treatment.
키워드
Substantia nigraNeurodegenerationHaploinsufficiencyParkinDopaminergicPINK1MPTPMitophagyNigrostriatal pathway