이재철 교수 연구실
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·2025
IGFBP2 Mediates Human iPSC-Cardiomyocyte Proliferation in a Cellular Contact-Dependent Manner
Soah Lee, Paul V. Heinrich, Daniel Lee, Yongwon Kang, Harley Robinson, Sean J. Humphrey, Jihye Yun, William R. Goodyer, Jan W. Buikema, David T. Paik, Francisco X. Galdos, Boyoung Kim, Nadjet Belbachir, Sungjin Min, Seung‐Woo Cho, Jaecheol Lee, Alessandra Moretti, Joseph C. Wu, James E. Hudson, Sean M. Wu
IF 16.2Circulation Research
초록
Our findings demonstrate that cell-cell contact inhibits hiPSC-CM proliferation through adherens junction formation, sarcomeric assembly, and reduced IGFBP2 secretion. Importantly, exogenous supplementation of IGFBP2 can overcome cell contact-mediated inhibition of hiPSC-CM proliferation and facilitate the growth of 3-dimensional cardiac tissue. These insights provide valuable implications for advancing cardiac tissue engineering and regenerative therapies.
키워드
Adherens junctionCell growthCellTissue engineeringSignal transductionCardiac cellCell type