박지영 교수 연구실
preprint|
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·인용수 0
·2025
Targeting the COP9 signalosome overcomes platinum resistance in ovarian cancer through two distinct genome stability mechanisms
Elena Lomonosova, Megan Loeb, Kevin Rodriguez, Lilian N. van Biljon, Joshua Brill, Angela M. Schab, Margaret Minett, J. Patrick Barron, Michael Bittner, Jiyoung Park, Rebecca Drexler, Carmen Sandoval, Alyssa Oplt, Eden Gallup, Prasanth Thuthika, Negar Sadeghipour, Sharon Wu, Matthew J. Oberley, Brooke E. Sanders, Lindsay M. Kuroki, Carolyn K. McCourt, Andrea R. Hagemann, Premal H. Thaker, David G. Mutch, Matthew A. Powell, Ian S. Hagemann, Ma. Xenia G. Ilagan, Katherine C. Fuh, Priyanka Verma, Orlando D. Schärer, Nima Mosammaparast, Dineo Khabele, Mary M. Mullen
bioRxiv (Cold Spring Harbor Laboratory)
초록
COPS5 depletion or inhibition using a small molecule COPS5 inhibitor CSN5i-3 sensitizes high-grade serous carcinoma to platinum chemotherapy through downregulation of nucleotide excision repair and interstrand crosslink repair.
키워드
CarboplatinOvarian cancerCisplatinNucleotide excision repairDNA damageCancer researchHomologous recombinationDNA repairBiologyUbiquitin