Sandwich panels are widely used in industrial roofing due to their lightweight and thermal insulation properties; however, their structural fire resistance remains insufficiently understood. This study presents a data-driven approach to predict the mid-span deformation of glass wool-cored sandwich roof panels subjected to ISO 834-5 standard fire tests. A total of 39 full-scale furnace tests were conducted, yielding 1519 data points that were utilized to develop deep learning models. Feature selection identified nine key predictors: elapsed time, panel orientation, and seven unexposed-surface temperatures. Three deep learning architectures—convolutional neural network (CNN), multilayer perceptron (MLP), and long short-term memory (LSTM)—were trained and evaluated through rigorous 5-fold cross-validation and independent external testing. Among them, the CNN approach consistently achieved the highest accuracy, with an average cross-validation performance of R2=0.91(meanabsoluteerror(MAE)=4.40;rootmeansquareerror(RMSE)=6.42), and achieved R2=0.76(MAE=6.52,RMSE=8.62) on the external test set. These results highlight the robustness of CNN in capturing spatially ordered thermal–structural interactions while also demonstrating the limitations of MLP and LSTM regarding the same experimental data. The findings provide a foundation for integrating machine learning into performance-based fire safety engineering and suggest that data-driven prediction can complement traditional fire-resistance assessments of sandwich roofing systems.