박승범 교수 연구실
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·인용수 76
·2012
Estrogen-related receptor γ controls hepatic CB <sub>1</sub> receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol
Don‐Kyu Kim, Yong‐Hoon Kim, Hyun-Hee Jang, Jinyoung Park, Jung Ran Kim, Minseob Koh, Won‐Il Jeong, Seung‐Hoi Koo, Tae‐Sik Park, Chul‐Ho Yun, Seung Bum Park, John Y.L. Chiang, Chul‐Ho Lee, Hueng-Sik Choi
IF 25.8Gut
초록
ERRγ, as a previously unrecognised transcriptional regulator of hepatic CB1 receptor, controls alcohol-induced oxidative stress and liver injury through CYP2E1 induction, and its inverse agonist could ameliorate oxidative liver injury due to chronic alcohol exposure.
키워드
Liver injuryOxidative stressEndocrinologyInternal medicineCYP2E1Alcoholic liver diseaseAgonistBiologyReceptorChemistry