The cover image depicts an industrial assembly line symbolizing the modular synthesis of pyritide-inspired macrocycles through a Build/Couple/Pair strategy. This streamlined and versatile approach enables the construction of structurally diverse, biologically relevant macrocycles incorporating bipyridine motifs. Among them, compound 6paW—featured at the center of the image—exhibits the most potent ferroptosis-inhibitory activity, as reported by Seung Bum Park and co-workers in their Research Article (e202518622).