As manufacturing transitions into the era of Industry 5.0, the demand for systems that are not only intelligent but also human-centric, resilient, and sustainable is becoming increasingly critical. This paper introduces the Human and Humanoid-in-the-Loop (HHitL) ecosystem, a novel framework that integrates both humans and humanoid robots as collaborative agents within cyber–physical manufacturing environments. Building on the foundational principles of Industry 5.0, the paper presents a 6P architecture that includes participation, purpose, preservation, physical assets, persistence, and projection. The core features of this ecosystem, including anthropomorphism, perceptual intelligence, cognitive adaptability, and dexterity/locomotion, are identified, and their enablers are also introduced. This work presents a forward-looking vision for next-generation manufacturing ecosystems where human values and robotic capabilities converge to form adaptive, ethical, and high-performance systems.