전종호 교수 연구실
paratext|
bronze
·인용수 1
·2013
Inside Cover: Positron Emission Tomography Imaging of Drug‐Induced Tumor Apoptosis with a Caspase‐Triggered Nanoaggregation Probe (Angew. Chem. Int. Ed. 40/2013)
Bin Shen, Jongho Jeon, Mikael Palner, Ye Deju, Adam J. Shuhendler, Frederick T. Chin, Jianghong Rao
IF 16.9Angewandte Chemie International Edition
초록
The caspase-3 activity in doxorubicin-treated tumor xenografts is studied by positron emission tomography (PET) using a novel 18F-labeled caspase-3-sensitive nanoaggregation tracer. In their Communication on page 10511 ff., J. Rao, F. T. Chin, et al. show that the enzyme-activatable tracer improves the PET imaging of apoptotic tumors by intramolecular macrocyclization and in situ aggregation of the cyclized tracer upon caspase-3 activation. (Picture: Jim Strommer and Lydia-Marie Joubert.)
키워드
Positron emission tomographyChemistryPet imagingApoptosisNuclear medicineCaspase 3MedicineBiochemistryProgrammed cell death