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·2025
Pulmonary Fibrosis in Critically Ill Patients With COVID-19: A Multi-Center Retrospective Cohort Study in Korea
Daehong Cho, Ganghee Chae, Joon-Sung Joh, Junghyun Kim, Tae Yun Park, Ae-Rin Baek, Won‐Young Kim, Yangjin Jegal, Chi Ryang Chung, Jinwoo Lee, Joo Hun Park, Jae Wook Lee, Soyeoun Lim, Jin Woo Song
IF 2.3Journal of Korean Medical Science
초록

BACKGROUND: Pulmonary fibrosis can persist long after recovery from coronavirus disease 2019 (COVID-19) infection, thereby reducing quality of life and lung function. We aimed to evaluate the frequency and risk factors for pulmonary fibrosis in patients with severe COVID-19 pneumonia requiring mechanical ventilation (MV), a high-risk group for developing pulmonary fibrosis. METHODS: Clinical data and chest computed tomography (CT) scans of patients with severe COVID-19 pneumonia requiring MV were retrospectively collected from nine hospitals in South Korea. Fibrotic-like changes on chest CT were visually assessed. RESULTS: = 0.018) was associated with a reduced risk of pulmonary fibrosis, along with a higher heart rate on intensive care unit admission. CONCLUSION: Our study demonstrated that in patients with severe COVID-19 pneumonia requiring MV, chest CT revealed fibrotic-like changes in approximately three-quarters of patients. In addition, our results suggest that higher daily doses of steroids may be associated with a reduced risk of pulmonary fibrosis. Further research is needed to determine the appropriate steroid dose that may reduce the progression of pulmonary fibrosis and improve clinical outcomes. TRIAL REGISTRATION: Clinical Research Information Service Identifier: KCT0006312.

키워드
MedicineCritically illRetrospective cohort studyCoronavirus disease 2019 (COVID-19)Pulmonary fibrosisIntensive care medicineCohortSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakCohort study
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article
IF / 인용수
2.3 / 0
게재 연도
2025

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