김은미 교수 연구실
article|
gold
·인용수 27
·2024
Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging
Siyi Zhou, Zeming Li, Xinzhu Li, Yuanli Ye, Mengyue Wang, Jingwei Jiang, Lihe Tao, Yan Wang, C.C. Tung, Yongji Chung ., Eun‐Mi Kim, Xinyu Shen, Xuegang Xu, Xiao Xiang, Qiaoli Xie, Jinwei Zhang, Wang Wu, Xia Lin, Cheng‐Ming Chuong, Mingxing Lei
Journal of Advanced Research
초록
Our finding reveals reciprocal interactions between ECs and DP. ECs releases EDN1 sensed by DP to activate TA metabolism which induces hair regeneration, while DP emits CTF1 signal received by ECs to enhance ALA metabolism which promotes angiogenesis. Our study provides new insights into mutualistic cellular crosstalk between hair follicles and blood vessels, and identifies novel signaling contributing to the interactions of hair follicles and blood vessels in normal and aged skin.
키워드
AngiogenesisCell biologyBiologyRegeneration (biology)CrosstalkDermal papillaeHair follicleCancer research