이창훈 교수 연구실
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·2025
ERK2-mediated phosphorylation of ZEB1 at S322 enhances PD-L1 expression and EMT, leading to pancreatic cancer progression
Mi Kyung Park, Hye Ja Lee, Jee Young Sung, Hyun Jung Byun, Hyun Ji Kim, Eun Ji Kim, Tuan Minh Nguyen, Gyeoung-Jin Kang, Seung Hyun Oh, Jae Gal Shim, Ho Lee, Ki Taek Nam, Yong Yun Kim, Seung Bae Rho, Sang Gun Kim, Chang Hoon Lee
Cell Communication and Signaling
초록
SPC induces ZEB1 phosphorylation, with ERK2, rather than ERK1, targeting the S322 site. Inhibiting S322 phosphorylation mitigates EMT, PD-L1 expression, and progression of pancreatic cancer. The phosphoS322 detection antibody might be a valuable tool for predicting pancreatic cancer prognosis. These findings implicate ERK2 as a potential therapeutic target for pancreatic cancer and highlight phosphoZEB1 as a valuable prognostic marker.
키워드
PhosphorylationPancreatic cancerCancer researchExpression (computer science)CancerMedicineBiologyInternal medicineCell biologyComputer science