기본 정보
연구 분야
프로젝트
논문
구성원
article|
gold
·인용수 21
·2025
Magnetically reshapable 3D multi-electrode arrays of liquid metals for electrophysiological analysis of brain organoids
Enji Kim, Eunseon Jeong, Yeon‐Mi Hong, Inhea Jeong, Jung-Hoon Kim, Yong Won Kwon, Young‐Geun Park, Jiin Lee, Suah Choi, Ju‐Young Kim, Jae‐Hyun Lee, Seung‐Woo Cho, Jang‐Ung Park
Nature Communications
초록

To comprehend the volumetric neural connectivity of a brain organoid, it is crucial to monitor the spatiotemporal electrophysiological signals within the organoid, known as intra-organoid signals. However, previous methods risked damaging the three-dimensional (3D) cytoarchitecture of organoids, either through sectioning or inserting rigid needle-like electrodes. Also, the limited numbers of electrodes in fixed positions with non-adjustable electrode shapes were insufficient for examining the complex neural activity throughout the organoid. Herein, we present a magnetically reshapable 3D multi-electrode array (MEA) using direct printing of liquid metals for electrophysiological analysis of brain organoids. The adaptable distribution and the softness of these printed electrodes facilitate the spatiotemporal recording of intra-organoid signals. Furthermore, the unique capability to reshape these soft electrodes within the organoid using magnetic fields allows a single electrode in the MEA to record from multiple points, effectively increasing the recording site density without the need for additional electrodes.

키워드
OrganoidElectrodeElectrophysiologyElectrode arrayMaterials scienceNanotechnologyBiomedical engineeringNeuroscienceChemistryBiology
타입
article
IF / 인용수
- / 21
게재 연도
2025

주식회사 디써클

대표 장재우,이윤구서울특별시 강남구 역삼로 169, 명우빌딩 2층 (TIPS타운 S2)대표 전화 0507-1312-6417이메일 info@rndcircle.io사업자등록번호 458-87-03380호스팅제공자 구글 클라우드 플랫폼(GCP)

© 2026 RnDcircle. All Rights Reserved.