김명철 교수 연구실
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·인용수 2
·2025
Diminished SUV3 expression and its functional implications in the IFN-enriched monocyte subset of childhood Sjögren’s disease
Jung‐Hoon Yoon, Daesong Jang, Myung‐Chul Kim, Joon Paek, Rehae Miller, Beatriz Veronese, Raquel Alvarado, Akaluck Thatayatikom, Yoosik Kim, Seunghee Cha
IF 4.4Lara D. Veeken
초록
SUV3 is the key driver for defective innate immune functions through mt-dsRNA-mediated PKR activation, which enhances cellular stress, mitochondrial dysfunction and inflammatory signatures, uncovering a novel mechanism in cSjD pathogenesis.
키워드
Gene knockdownProtein kinase RInnate immune systemCell biologyRNA silencingBiologyPhagocytosisCD14Proinflammatory cytokineMolecular biology