박진규 교수 연구실
article|
인용수 85
·2017
An endoplasmic reticulum protein, Nogo‐B, facilitates alcoholic liver disease through regulation of kupffer cell polarization
Jin‐Kyu Park, Mingjie Shao, Moon Young Kim, Soon Koo Baik, Mee-Yon Cho, Teruo Utsumi, Ayano Satoh, Xinsho Ouyang, Chuhan Chung, Yasuko Iwakiri
IF 15.8Hepatology
초록
Nogo-B is permissive of M1 polarization of Kupffer cells, thereby accentuating liver injury in ALD in humans and mice. Nogo-B in Kupffer cells may represent a new therapeutic target for ALD. (Hepatology 2017;65:1720-1734).
키워드
Alcoholic liver diseaseEndoplasmic reticulumKupffer cellInternal medicineUnfolded protein responseEndocrinologySteatosisLiver injuryPathogenesisChemistry