박진규 교수 연구실
article|
인용수 66
·2009
Vitamin C Deficiency Attenuates Liver Fibrosis by Way of Up-Regulated Peroxisome Proliferator-Activated Receptor-Gamma Expression in Senescence Marker Protein 30 Knockout Mice
Jin‐Kyu Park, Mi‐Ran Ki, Hye-Rim Lee, Il‐Hwa Hong, Ae‐Ri Ji, Akihito Ishigami, Se‐Il Park, Jimin Kim, Hae‐Young Chung, Sung‐Eun Yoo, Kyu‐Shik Jeong
IF 15.8Hepatology
초록
Vitamin C deficiency by SMP30 depletion attenuated liver fibrosis by way of up-regulated PPAR-gamma expression in SMP30 KO mice. Our results provide, for the first time, the possible mechanisms underlying inhibition of HSC activation associated with vitamin C and PPAR-gamma up-regulation in liver fibrosis of SMP30 KO mice.
키워드
EndocrinologyInternal medicineFibrosisKnockout mouseHepatic stellate cellPeroxisome proliferator-activated receptorVitaminBiologyReceptorChemistry