Cancer Therapy As glycocalyx-directed binding interactions are prevalent in cancer cells and are used for cell–cell communication and cell adhesion through carbohydrate-mediated interactions, Hee-Seung Lee, Sangyong Jon, and co-workers have developed a nanomedicine platform based on a library of glycocalyx-mimicking nanoparticles that enables screening and identification of cancer-cell-selective glyconanoparticles, as described in article number 2203993. This work demonstrates the potential of the glycocalyx-mimicking nanoparticle platform for use in targeted cancer therapy.