Drug Delivery In article number 2311283, Hee-Seung Lee, Sangyong Jon, and co-workers have develop an organ-selective drug delivery platform based on a library of glycocalyx-mimicking nanoparticles (GlyNPs). Direct in vivo library screening enable identification of GlyNP hits targeting liver, spleen, lung, kidneys, heart, and brain and, moreover, each organ-selective GlyNP hit shows cellular tropism within the organ. When liver-, kidney-, and spleen-selective GlyNP hits are equipped with therapeutics, the formulations effectively alleviated symptoms in organ-associated disease models.