The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Table S1: Baseline characteristics of the Con-Tx, anti-IL5/IL5R therapy, and anti-IL4R groups in the mediation analysis datasets. Table S2: Sensitivity analysis of mediation effects across varying ρ (rho) values. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.