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·2026
Suicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy
Sarah Barnard, Jacqueline A. French, Zeli Chen, Manisha Holmes, Manu Hegde, Hamada Altalib, Melodie R. Winawer, Michael Sperling, Nathalie Jetté, Omotola Hope, Siddhartha Nadkarni, Terence J. O’Brien, Ruben Kuzniecky, DH Lowenstein, A.M. Kanner, Human Epilepsy Project Investigators, Alexis Boro, Andrew Cole, Andy Rodriguez, Barry E. Gidal, Bassel Abou-Khalil, Brandy Fureman, Brian K. Alldredge, Caroline Neuray, C. Ákos Szabó, Chris Morrison, Dale C. Hesdorffer, David M. Ficker, David Gloss, Dennis Dlugos, Edward Faught, Elisabeth Schmid, Eric B. Geller, Ernest Somerville, Eugen Trinka, Gary Cutter, Graeme D. Jackson, Gregory Cascino, Gregory L. Krauss, Gregory Worrell, Heath Pardoe, James C. Cloyd, Jerzy P. Szaflarski, John Hixson, J. H. Pollard, Jonathan J. Halford, Joon Won Kang, Jorge G. Burneo, Judy Weisenberg, Kamil Detyniecki, Kimford J. Meador, Kristen Park, Lara Marcuse, Liu Lin, Mary J. Brandon, Madeline Fields, Mangala A. Nadkarni, Margarita Kirschner, Martina Bebin, Orrin Devinsky, Patricia Penovich, Patrick Kwan, Paul Atkinson, Pavel Klein, Peter Widdess-Walsh, Rani K. Singh, Reeta Kälviäinen, Robert C. Knowlton, Scott Mintzer, Sheryl R. Haut, Simon Glynn, Susan Herman, Tracy A. Glauser, Tricia Y. Ting
JAMA Neurology
초록
Results of this cohort study reveal that suicidality at the time of focal epilepsy diagnosis was associated with future drug resistance and may be a marker of more severe neuropathology. Psychiatric screening at time of diagnosis may facilitate early identification of patients at risk for treatment refractory epilepsy syndromes.
키워드
EpilepsyCohortRefractory (planetary science)Cohort studyDrug Resistant EpilepsyPoison controlYoung adultDrug resistance