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·2025
Enhanced anti-tumor efficacy of tumor-infiltrating lymphocytes by GITR agonist in ovarian cancer
Daun Jung, Ai Sim Goh, Ki Yeon Kim, Ji Min Lee, Eun Ji Lee, Sohyun Hwang, Haeyoun Kang, Hyun Park, Hee Jung An
IF 5.9Frontiers in Immunology
초록
Taken together, we demonstrated that the addition of an agonistic GITR antibody during the early phase of TIL culture increased the CD8<sup>+</sup> T cell to Treg cell ratio and enhanced anti-tumor T cell immunity. Enhancing TILs with a GITR agonist may be beneficial for improving the clinical outcomes of TIL-based ACT in OC.
키워드
AgonistOvarian cancerT cellAntibodyCellCell growthTumor-infiltrating lymphocytesImmunotherapyCancer