예상규 교수 연구실
preprint|
gold
·인용수 0
·2025
Figure S6 from Denfivontinib Activates Effector T Cells Through the NLRP3 Inflammasome, Yielding Potent Anticancer Effects by Combination with Pembrolizumab
Dong Kwon Kim, Chun‐Bong Synn, Wongeun Lee, Ha-Ni Jo, Chai Young Lee, Seul Lee, Joon Yeon Hwang, Youngtaek Kim, Seong-san Kang, Sujeong Baek, Kwangmin Na, Seung M. Yang, Mi H. Kim, Heekyung Han, Yu J. Han, Jae Hwan Kim, So Young Park, YoungJoon Park, Gang-Taik Lee, Su‐Jin Choi, Jie-Ohn Sohn, Sang‐Kyu Ye, Jii Bum Lee, Sun Min Lim, Min Hee Hong, Kyoung‐Ho Pyo, Byoung Chul Cho
초록
<p>a Sing-cell RNA sequencing data was clustered and annotated using Azimuth cell annotation methods. b The cells were re-clustered into subpopulations. c Each cluster was verified using the top marker genes. d The clusters were separated into treatment groups. e Enhanced volcano plot showing enriched cluster genes using DEG analysis. f Dittobar plot showing the different proportions of subsets in the groups. g Re-clustering of the T-cell clusters. h Re-clustering of macrophage clusters. DEG, differentially expressed genes</p>
키워드
InflammasomePembrolizumabEffectorCancer researchBiologyImmunologyImmune systemImmunotherapyInflammation