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김남주 연구실
분당서울대학교 김남주 교수
Thyroid eye disease
clinical activity score
periocular photography
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김남주 연구실

분당서울대학교 김남주 교수

김남주 연구실은 분당서울대학교병원 소속으로, 안과 영역에서 질병 활성도와 수술 예후를 객관화하는 연구를 수행합니다. Thyroid eye disease에서는 periocular 사진 및 디지털 안면 이미지를 이용해 clinical activity score를 정량 평가하거나 기계학습 기반으로 예측하는 접근을 수행하고, 혈청 microRNA 프로파일링과 qRT-PCR 검증으로 활성도 바이오마커를 발굴합니다. 또한 비루관 질환에서는 CT 및 전안부 OCT 지표를 활용해 실리콘 튜브 삽입의 성공 관련 인자를 분석하며, 눈꺼풀 수술 후에는 meibography, interferometer, 각막 상태를 정량화해 meibomian gland와 각막 안전성을 평가합니다.

Thyroid eye diseaseclinical activity scoreperiocular photographyserum microRNAmeibomian gland
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Thyroid eye disease 활동도 자동/정량 평가 연구 thumbnail
Thyroid eye disease 활동도 자동/정량 평가 연구
Automated and quantitative assessment of Thyroid Eye Disease activity
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연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

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주요 논문
5
논문 전체보기
1
article
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인용수 0
·
2025
Photographic evaluation of clinical activity score in thyroid eye disease
Gyeong Min Lee, Min Joung Lee, Namju Kim, Ho-Kyung Choung, Hwa Lee, Won‐Kyung Cho, Jae Hoon Moon, Sang In Khwarg
IF 2.6 (2025)
PLoS ONE
PURPOSE: Given the subjective nature of clinical activity score (CAS) and variability between observers, this study evaluated the inter-observer variability of soft tissue signs (STS) in the CAS using periocular photographs and compared the diagnostic performance of photographic CAS (P-CAS) with clinical assessment for detecting active thyroid eye disease (TED). METHODS: This retrospective cohort study included 754 TED patients who underwent periocular photography at Seoul National University Bundang Hospital between 2006 and 2021. Five oculoplastic specialists independently evaluated five STS of CAS using periocular photographs. Inter-observer agreement and concordance between photographically (P-STS) and clinically (C-STS) assessed STS, assessment consistency, were analyzed using Kappa statistics. Diagnostic accuracy of P-CAS was evaluated via receiver operating characteristic (ROC) curves with additional analysis incorporating demographic variables such as sex, age, and smoking dose. RESULTS: Assessment consistency was moderately good for redness of eyelid and conjunctiva (Kappa = 0.418, 0.499). The diagnostic performance of P-CAS (area under the curve, AUC = 0.774) was lower than that of clinical CAS (C-CAS) (AUC = 0.818, p = 0.007), However, it significantly improved when demographic factors were added (AUC = 0.851). CONCLUSION: Periocular photography provides a reproducible and clinically valuable adjunct for assessing TED activity. The redness-related items showed higher agreement than swelling-related ones, and integrating demographic variables enhances diagnostic performance. This approach may contribute to standardizing TED assessment and serve as a foundation for future automated or image-based evaluation tools.
https://doi.org/10.1371/journal.pone.0337597
Thyroid
Eye disease
Disease
Thyroid disease
Photography
MEDLINE
2
article
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인용수 7
·
2023
Serum microRNA as a potential biomarker for the activity of thyroid eye disease
Namju Kim, Ho-Kyung Choung, Kwang Gi Kim, Sang Earn Woo, Min Kyu Yang, Sang In Khwarg, Min Joung Lee
IF 3.8 (2023)
Scientific Reports
The aim of this study is to characterize the microRNA (miRNA) expression signatures in patients with thyroid eye disease (TED) and identify miRNA biomarkers of disease activity. Total RNA was isolated from the sera of patients with TED (n = 10) and healthy controls (HCs, n = 5) using the miRNeasy Serum/Plasma Kit. The NanoString assay was used for the comprehensive analysis of 798 miRNA expression profiles. Analysis of specific miRNA signatures, mRNA target pathway analysis, and network analysis were performed. Patients with TED were divided into two groups according to disease activity: active and inactive TED groups. Differentially expressed circulating miRNAs were identified and tested using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) tests in the validation cohort. Among the 798 miRNAs analyzed, 173 differentially downregulated miRNAs were identified in TED patients compared to those in the HCs. Ten circulating miRNAs were differentially expressed between the active and inactive TED groups and regarded as candidate biomarkers for TED activity (one upregulated miRNA: miR-29c-3p; nine downregulated miRNAs: miR-4286, miR-941, miR-571, miR-129-2-3p, miR-484, miR-192-5p, miR-502-3p, miR-597-5p, and miR-296-3p). In the validation cohort, miR-484 and miR-192-5p showed significantly lower expression in the active TED group than in the inactive TED group. In conclusion, the expression levels of miR-484 and miR-192-5p differed significantly between the active and inactive TED groups, suggesting that these miRNAs could serve as circulating biomarkers of TED activity, however, these findings need to be validated in further studies.
https://doi.org/10.1038/s41598-023-27483-w
microRNA
Biomarker
Downregulation and upregulation
Fold change
Real-time polymerase chain reaction
Cohort
Disease
Medicine
Reverse transcription polymerase chain reaction
Biology
3
article
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인용수 11
·
2022
Bony nasolacrimal duct size and outcomes of nasolacrimal silicone intubation for incomplete primary acquired nasolacrimal duct obstruction
Min Kyu Yang, Ho‐Seok Sa, Namju Kim, Jeong Hun Kim, Ho-Kyung Choung, Sang In Khwarg
IF 3.7 (2022)
PLoS ONE
PURPOSE: To investigate the association between the bony nasolacrimal duct (NLD) size and outcomes of nasolacrimal silicone intubation for incomplete primary acquired nasolacrimal duct obstruction (PANDO). METHODS: Patients who underwent silicone intubation for incomplete PANDO and had undergone facial computed tomography (CT) were included. Surgical success was judged by both epiphora improvement and normalized tear meniscus height (TMH; < 300 μm) on anterior segment optical coherence tomography at 3 months after tube removal. The area, major axis diameter, and minor axis diameter of the elliptic bony NLD sections were measured in 1.0 mm-thick axial CT images. These bony NLD sizes were analyzed for associations with surgical success and TMH normalization. RESULTS: Eighty-one eyes of 48 patients were investigated. The smallest area and the smallest minor axis diameter were significantly larger in the success group (49 eyes), compared with those in the failure group (median smallest minor axis diameter: 4.7 mm vs. 3.8 mm, P = 0.008, Mann-Whitney U test). There was also a tendency for the TMH normalization rate to significantly increase as the smallest area and the smallest minor axis diameter increased (P = 0.028 and 0.037, respectively, Fisher's 2 × 4 tests). Under multivariable logistic regression analysis using generalized estimating equation, a larger smallest minor axis diameter was associated with success of the nasolacrimal silicone intubation (odds ratio: 2.481, 95% confidence interval: 1.143-5.384). CONCLUSION: Surgical success of the nasolacrimal silicone intubation in incomplete PANDO is associated with a larger smallest minor axis diameter of the bony NLD. This finding will help understand the pathophysiology of surgical failure after nasolacrimal silicone intubation.
https://doi.org/10.1371/journal.pone.0266040
Nasolacrimal duct
Nasolacrimal duct obstruction
Intubation
Medicine
Confidence interval
Craniofacial
Silicone
Surgery
Internal medicine
Materials science

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