구태윤 교수 연구실
preprint|
green
·인용수 0
·2025
Proteomic Analysis in Alzheimer’s Disease with Psychosis Reveals Separate Molecular Signatures for Core AD Proteinopathy and Postsynaptic Density Disruption
Taeyun Ku, Steven J. Mullett, Sui Zhang, Li Zeng, Ying Ding, Anastasia K. Yocum, Marcy E. MacDonald, Stacy L. Gelhaus, Julia Kofler, Robert A. Sweet
bioRxiv (Cold Spring Harbor Laboratory)
초록
Our findings suggest a model in which AD+P arises from the combination of quantitative alterations within a shared AD proteome profile and a superimposed set of protein alterations correlated with PSD yield that are largely independent of the shared AD proteome, conferring distinct mechanisms of synaptic vulnerability and psychosis risk.
키워드
ProteomePsychosisDiseasePostsynaptic densityVulnerability (computing)Postsynaptic potentialCore (optical fiber)Set (abstract data type)