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·인용수 2
·2025
Phase-Locked Time-Stretch Optical Coherence Tomography for Contrast-Enhanced Retinal Microangiography
Gyeong Hun Kim, Seongjin Bak, Hyung Hoi Kim, Jun Geun Shin, Tae Joong Eom, Chang‐Seok Kim, Hwidon Lee
IF 9.8IEEE Transactions on Medical Imaging
초록

Optical coherence tomography angiography has transformed retinal vascular imaging by providing non-invasive, high-resolution visualization. However, achieving an optimal balance between field of view, resolution, and three-dimensional microvasculature contrast, particularly in deeper retinal layers, remains challenging. A phase-locked time-stretch optical coherence tomography microangiography system is developed to address these limitations with a 5-MHz A-line rate and sub-nm phase sensitivity. Utilizing a dual chirped fiber Bragg grating architecture, the swept-source laser achieves an extended coherence length of ~10 mm and a 102-nm bandwidth. A time-stretch analog-to-digital converter overcomes the limitations of conventional multi-MHz optical coherence tomography systems, ensuring a 2-mm imaging depth in the air with high spatial resolution. The proposed system enables high-contrast, depth-encoded mapping of key retinal structures, including the superficial and deep capillary plexuses and the choriocapillaris. Compared to a state-of-the-art system, the proposed approach demonstrates enhanced resolution, improved contrast, and faster imaging speeds, enhancing its potential for diagnosing and monitoring retinal and systemic diseases like age-related macular degeneration, diabetic retinopathy, and Alzheimer's disease.

키워드
MicroangiographyOptical coherence tomographyRetinalContrast (vision)OpticsTomographyCoherence (philosophical gambling strategy)Phase contrast microscopyOptical tomographyMaterials science
타입
article
IF / 인용수
9.8 / 2
게재 연도
2025