MRSA Phototherapy In article number 2203292, Weiliang Xia, Yingzheng Zhao, Yijie Chen, and co-workers show that Van-Lipo(IR780)-PFC (an oxygen-carrying perfluorocarbon nanoemulsion stabilized by a vancomycin-functionalized sphingo-myelin liposome loaded with IR780) can capture methicillin-resistant Staphylococcus aureus (MRSA) toxins in situ, resulting in the on-demand release of phototherapeutic agents, thus improving the specificity of photothermal therapy/photodynamic therapy under near-infrared irradiation. Meanwhile, pore formation upon the insertion of toxins into the nanoparticles results in the generation of vaccines in situ, thus leading to an anti-MRSA immune response.