허주영 교수 연구실
article|
gold
·인용수 7
·2025
Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice
Shiyue Sun, Tongtong Yu, Joo Young Huh, Yujie Cai, Somy Yoon, Hafiz Muhammad Ahmad Javaid
IF 4.4Skeletal Muscle
초록
AGH treatment restored mitochondrial autophagy, reduced oxidative stress, apoptosis, and altered muscle fiber composition via the AKT/FOXO1 pathway, collectively improving muscle force in mdx mice. We propose AGH as a potential therapeutic strategy for DMD and related muscle disorders.
키워드
Duchenne muscular dystrophyOxidative stressmdx mouseGlutathione peroxidaseMitophagyPINK1AutophagyReactive oxygen speciesDystrophinBiology