Highly Sensitive Liquid Biopsies for Cancer Diagnosis MUTE-seq is an innovative technique that employs an advanced-fidelity CRISPR-based system to enable highly sensitive liquid biopsies for cancer diagnosis. The image illustrates how MUTE-seq solves the classic “needle in a haystack” problem. A dense cylindrical haystack of wild-type cfDNA that conceals a single mutant ctDNA—the “needle”—precisely illuminated by a CRISPR-guided light beam. More details can be found in the Research Article by Yonggoo Kim, Song Cheol Kim, Sungho Lee, Junho K. Hur, Junseok W. Hur, and co-workers (DOI: 10.1002/adma.202505208).