About a fourth of A+ patients in Korea met AUR criteria for anti-amyloid therapy. Donanemab eligibility slightly exceeded lecanemab despite narrower age criteria. MMSE z-score adjustment increased eligibility in older, less-educated individuals. Over 30% of eligible patients were excluded due to ARIA-related MRI findings. Culturally adapted cognitive thresholds are essential for equitable treatment access.

About a fourth of A+ patients in Korea met AUR criteria for anti-amyloid therapy. Donanemab eligibility slightly exceeded lecanemab despite narrower age criteria. MMSE z-score adjustment increased eligibility in older, less-educated individuals. Over 30% of eligible patients were excluded due to ARIA-related MRI findings. Culturally adapted cognitive thresholds are essential for equitable treatment access.

Title: A Study of Possibility of Using Regulatory T Cells (VT301) for Treatment of Alzheimer's Disease, ClinicalTrials.gov NCT05016427, Study approval date: Ministry of Food and Drug Safety of the Republic of Korea (MFDS) - August 31st, 2020, Institutional Review Board (IRB) of Seoul National University Hospital, Republic of Korea - September 29th, 2020, The date of first patient enrollment: December 7th, 2020. https://clinicaltrials.gov/study/NCT05016427.

This study confirmed the association of PSU and depression among general adult population and the precedence of MDD to PSU. Even previously resolved depression was found to affect current PSU.

Age, SDI score, and depression status were risk factors for frailty in patients with SLE. In addition, lower social support scores were associated with increases of depression status and frailty in patients with SLE. Therefore, active social support may be important for improving depression status and preventing frailty in patients with SLE.

Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

This study provides inaugural evidence on the effectiveness of S-ICM services, supporting their standardization and potential nationwide expansion.

Abstract Background Although many studies have consistently demonstrated the association between depression and problematic smartphone use (PSU), the temporal precedence and causality of this relationship remain controversial. Aims & Objectives This study aimed to investigate the relationship between major depressive disorder (MDD) and PSU in a sample of the general adult population by analyzing the association between present PSU and both past and current MDD. Method The study utilized data from the Korean Epidemiologic Catchment Area study, a nationwide epidemiologic survey that employed a multistage cluster sampling method. Participants were assessed using the Korean version of the Composite International Diagnostic Interview to diagnose MDD and the Smartphone Overuse Screening Questionnaire to identify PSU. Results Of the 916 subjects, 139 (15.2%) belonged to the PSU group. The prevalence of PSU in older adults was substantial, with 9.3% for the 36-50 age group and 5.4% for the over 50 age group. We found a significant association between MDD and PSU. Both current (OR 6.366, 95% CI 1.253-32.353) and previous (OR 2.826, 95% CI 1.528-5.227) MDD episodes were associated with increased risk of PSU. Discussion & Conclusion This study confirmed the association between PSU and MDD among the general adult population. Specifically, previously resolved depression was found to affect the current PSU. This study also contributes to the literature by utilizing standardized tools for diagnosing MDD, providing more robust evidence on the association between depression and PSU. Additionally, the study also highlighted that PSU is not limited to young populations.