Epicardial delivery of VEGF and cardiac stem cells guided by 3-dimensional PLLA mat enhancing cardiac regeneration and angiogenesis in acute myocardial infarction
Hye Jin Chung, Jong‐Tae Kim, Hee-Jung Kim, Hei-Won Kyung, Pramila Katila, Jeong-Han Lee, Tae‐Hyun Yang, Young-Il Yang, Seung Jin Lee
Clinical significance of elevated serum soluble CD40 ligand levels as a diagnostic and prognostic tumor marker for pancreatic ductal adenocarcinoma
Hye Jin Chung, Jong‐Baeck Lim
IF 7.5
Journal of Translational Medicine
Serum sCD40L is correlated with immunosuppression and angiogenesis in PDAC carcinogenesis/progression, and is a promising diagnostic and prognostic biomarker for PDAC superior to CA19-9 and CEA.
p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
Jae Kim, Eun-Kyung Yoon, Hye Jin Chung, Seong-Yeol Park, Kyeong-Man Hong, Chang Hun Lee, Yeon-Su Lee, Kyungho Choi, Young Yang, Kyung‐Tae Kim, In-Hoo Kim
Epicardial delivery of VEGF and cardiac stem cells guided by 3-dimensional PLLA mat enhancing cardiac regeneration and angiogenesis in acute myocardial infarction
Hye Jin Chung, Jong‐Tae Kim, Hee-Jung Kim, Hei-Won Kyung, Pramila Katila, Jeong-Han Lee, Tae‐Hyun Yang, Young-Il Yang, Seung Jin Lee
Clinical significance of elevated serum soluble CD40 ligand levels as a diagnostic and prognostic tumor marker for pancreatic ductal adenocarcinoma
Hye Jin Chung, Jong‐Baeck Lim
IF 7.5
Journal of Translational Medicine
Serum sCD40L is correlated with immunosuppression and angiogenesis in PDAC carcinogenesis/progression, and is a promising diagnostic and prognostic biomarker for PDAC superior to CA19-9 and CEA.
p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
Jae Kim, Eun-Kyung Yoon, Hye Jin Chung, Seong-Yeol Park, Kyeong-Man Hong, Chang Hun Lee, Yeon-Su Lee, Kyungho Choi, Young Yang, Kyung‐Tae Kim, In-Hoo Kim
Efficient Stereoselective Synthesis of Vepdegestrant (ARV‐471) via Ruthenium‐Catalyzed Asymmetric Hydrogenation
Neerasa Jayaprakash, Byeonggwan Kim, Hye Jin Chung
IF 2
ChemistrySelect
Abstract Vepdegestrant (ARV‐471) is a novel estrogen receptor (ER) degrader currently under clinical evaluation for the treatment of ER‐positive and HER2‐negative breast cancer. We have developed an efficient catalytic stereoselective synthetic route to produce this important compound. The key step involves a Ruthenium‐catalyzed asymmetric hydrogenation, which establishes the critical stereocenter with exceptional diastereoselectivity(>99% de). This method obviates the need for chiral chromatographic separation, thereby significantly improving the efficiency and scalability of the synthetic sequence compared to previously reported approaches.
The Korean Society for the Study of Moral Education
The moral law and the idea of freedom are the core concepts of Kant’s ethics. Through consideration of this concept, this study revealed what Kant has done in the field of ethics. Kant revealed that there is ‘the cause of freedom’ in humans, and that the cause of freedom is a ‘logical cause’ in that it is a regulation in the practical aspect of ‘pure reason’. What Kant did in the first critique revealed that human cognitive behavior contains ‘pure reason’ as an a priori condition of perception that is not explained only by sensory experience, revealing the metaphysics in epistemology. What Kant did in ethics was reveal that it is none other than metaphysics as a ‘practical use of pure reason’ that enables human moral behavior by revealing the idea of freedom as the basis for the establishment of moral behavior. Based on this, this study examined the characteristics of the second critique seen in relation to the first criticism. Given that the first critique is Kant’s metaphysics, which deals with the outline and fundamentals of the entire system of Kant’s philosophy, and the second critique is Kant’s moral philosophy, which deals with Kant’s ethical criticism in earnest based on the first critique it was discussed that the two critique are related to the metaphysical foundation of Kant’s ehics and that they are also related to epistemology and ethics and metaphysics. Furthermore, this discussion also revealed that its justification can only be secured from a metapraxis perspective (from the perspective of heart cultivation).