Microneedles (MNs) have been extensively investigated for transdermal delivery of large-sized drugs, including proteins, nucleic acids, and even extracellular vesicles (EVs). However, for their sufficient skin penetration, conventional MNs employ long needles (≥ 600 μm), leading to pain and skin irritation. Moreover, it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery. Herein, a dually amplified transdermal patch (MN@EV/SC) is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopus-inspired suction cup (SC) with short MNs (≤ 300 μm). While leveraging the suction effect to induce nanoscale deformation of the stratum corneum, MN@EV/SC minimizes skin damage and enhances the adhesion of MNs, allowing EV to penetrate deeper into the dermis. When MNs of various lengths are applied to mouse skin, the short MNs can elicit comparable corticosterone release to chemical adhesives, whereas long MNs induce a prompt stress response. MN@EV/SC can achieve a remarkable penetration depth (290 µm) for EV, compared to that of MN alone (111 µm). Consequently, MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice. Overall, MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort.

Microneedles (MNs) have been extensively investigated for transdermal delivery of large-sized drugs, including proteins, nucleic acids, and even extracellular vesicles (EVs). However, for their sufficient skin penetration, conventional MNs employ long needles (≥ 600 μm), leading to pain and skin irritation. Moreover, it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery. Herein, a dually amplified transdermal patch (MN@EV/SC) is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopus-inspired suction cup (SC) with short MNs (≤ 300 μm). While leveraging the suction effect to induce nanoscale deformation of the stratum corneum, MN@EV/SC minimizes skin damage and enhances the adhesion of MNs, allowing EV to penetrate deeper into the dermis. When MNs of various lengths are applied to mouse skin, the short MNs can elicit comparable corticosterone release to chemical adhesives, whereas long MNs induce a prompt stress response. MN@EV/SC can achieve a remarkable penetration depth (290 µm) for EV, compared to that of MN alone (111 µm). Consequently, MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice. Overall, MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort.

Intrinsically Stretchable Skin-Adhesive Actuator In article number 2503781, Gwanghyun Jo, Tae-Heon Yang, Changhyun Pang, and co-workers report a soft, skin-adhesive actuator that delivers high-fidelity vibration even under extreme stretching and bending. The actuator features a dielectric layer with anisotropic multiphase microarchitectures, seamlessly integrated with a stretchable electrode and a bio-inspired adhesive interface, enabling stable vibration performance beyond resonance frequencies and conformal contact with the skin. This platform offers a reliable solution for soft robotics, human–machine interfaces, and immersive haptic technologies.

Abstract Continuously printable electronics have the significant advantage of being efficient for fabricating conductive polymer composites; however, the precise tailoring of the 3D hierarchical morphology of conductive nanocomposites in a simple dripping step remains challenging. Here, we introduce a one‐step direct printing technique to construct diverse microdome morphologies influenced by the interfacial Marangoni effect and nanoparticle interactions. Using a jet dispenser for continuous processing, we effectively fabricated a soft epidermis‐like e‐skin containing 64 densely arrayed pressure sensing pixels with a hierarchical dome array for enhanced linearity and ultrasensitivity. The e‐skin has 36 temperature‐sensing pixels in the outer layer, with a shield‐shaped dome that is insensitive to pressure stimuli. Our prosthetic finger inserted with the printed sensor arrays was capable of ultragentle detection and manipulation, such as stably holding a fragile biscuit, using a soft dropper to elaborately produce water droplets and harvesting soft fruits; these activities are challenging for existing high‐sensitivity tactile sensors. image

Continuous physiological signal monitoring and diagnosis are crucial for proactive health management and timely interventions. Key challenges include achieving non-toxic adhesion of stretchable conductors to dynamic skin and integration with lightweight, wearable circuits equipped diagnosing algorithms. We propose wireless physiological monitoring with vital diagnosis, featuring octopus-inspired micromembrane structure electrodes that enhance both adhesion and permeability. These stretchable electrodes exhibit a conductivity of over 2700 S/cm and maintain stretchability up to 1000 %, with minimal degradation after 1000 cycles of deformation. Adhesion reaches 12 kPa, ensuring durability for over 1000 attachment-detachment cycles and long-term attachment exceeding 24 h without skin toxicity. The system, connected to a miniaturized wireless circuit (2.8 g), facilitates real-time, accurate collection of electrocardiography (ECG), electromyography (EMG), electrooculography (EOG), and electroencephalography (EEG) signals. As proof of concept, ECG signals from real subjects processed with a transfer-learning algorithm achieved over 93.3 % diagnostic accuracy, paving the way for reliable, personalized health monitoring. • Achieved record-high conductivity (2700 S/cm) and 1000 % stretchability in a long-term stable stretchable conductor. • Skin-adhesive conductor maintained performance under 1000 cycles of strain, stretch, adhesion, and bio-signal reliability. • Wireless ECG monitoring showed over 93.3 % prediction accuracy using data from 15 individuals with normal heart rhythms.

Rapid and spatial temperature measurement on the skin is essential for detecting localized physiological anomalies, such as inflammation or circulatory issues, while providing insights into thermoregulation. Skin-conformal temperature sensors, with ultra-flexible designs, enable precise and comfortable measurements, supporting real-time monitoring, early diagnosis, and effective intervention. However, achieving rapid and spatial skin-conformal temperature sensor arrays that simultaneously maintain high sensitivity under extreme mechanical stresses remains a significant challenge. This work introduces a skin-conformal temperature sensor array based on a composite of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) and Ag flakes, fabricated on a 2-µm-thick parylene-C substrate. A simple mixing process achieves uniform dispersion of Ag flakes, enhancing electrical conductivity to 2.04 kS cm^-1. The sensor demonstrates a temperature coefficient of resistance of -2.02%/°C (30-50 °C), a resolution of 0.5 °C, and a rapid response time under 0.41 s per 5 °C change. It endures over 1000 cycles of 200% strain and performs reliably under 3 µm bending radii. Demonstrating high-resolution sensitivity and spatial temperature mapping through letter pattern recognition, the sensor shows promise for applications in body temperature monitoring, thermal imaging, and early diagnosis of temperature-related health conditions.

Molecular tracing of extremely low amounts of biofluids is vital for precise diagnostic analysis. Although optical nanosensors for real-time spatiotemporal molecular tracing exist, integrating them into simple devices that capture low-volume fluids on rough, dynamic surfaces remains challenging. We present a bioinspired 3D microstructured patch monolithically integrated with optical nanosensors (3D MIN) for real-time, multivariate molecular tracing of ultralow-volume fluids. Inspired by tree frog toe pads, the 3D MIN features soft, hexagonally aligned pillars and microchannels for conformal adhesion and targeted fluid management. Embedding near-infrared fluorescent single-walled carbon nanotube nanosensors in a hydrogel enables simultaneous fluid capture and detection. Softening the elastomer microarchitecture and optimizing water management promote stable adhesion on wet biosurfaces, allowing rapid collection of ultralow-volume fluids (~0.1 µL/min·cm²). We demonstrate real-time, remote sweat analysis with ≥75 nL volumes collected in 45 s, without exercise or iontophoresis, showcasing high biocompatibility and efficient spatiotemporal molecular tracing.

For highly efficient and precise drug release, transdermal drug delivery systems (TDDS) have recently evolved through the combination of intelligent material-based structures with various active components. These strategies are an effort to overcome the significant difficulties in delivering large molecule drugs and nanomaterials due to the physical barrier of the skin, especially the stratum corneum, in traditional TDDS. Interestingly, multiscale suction-driven architectures (SDAs) inspired by bioinspired suction adhesion mechanisms have provided innovative solutions to these challenges. These architectures employ negative pressure to enhance nanoscale skin-controllable skin adhesion, temporarily bypass the skin barrier, and facilitate deep penetration of therapeutic agents, thereby, achieving the goals of increasing drug delivery efficiency and maximizing user convenience as a minimal invasive, needle-free platform. This review provides a comprehensive overview of suction-driven transdermal patches and emphasizes their integration with multifunctional materials to achieve stable adhesion and controlled drug release. Next, we present cost-effective and user-friendly suction-driven drug delivery patch devices through optimization of cupping structures without the incorporation of additional devices. Furthermore, we present cost-effective and user-friendly transdermal drug delivery patch devices that optimize multiscale cupping architectures without the need for additional devices. Potential of bioinspired SDAs in localized and systemic drug delivery through challenging and complex skin, as well as future perspectives, are discussed, along with innovative directions for more efficient and patient-centric transdermal drug delivery solutions.