The rapid growth of nanotechnology and spectroscopic techniques has accelerated the development of biosensors with high sensitivity and selectivity. Nanoscale metasurfaces can potentially overcome the limitations of conventional optical methods, such as low responsivity and molecular specificity. One promising approach for analyzing subtle biochemical changes that occur in complex biological phenomena is to use terahertz metasurfaces. Here, the aim is to develop a dual-selective terahertz nanodisc metasurface that enabled precise monitoring of neurotransmitter dynamics in a biomimetic environment. Utilizing functionalized terahertz metasurfaces with nanodisc that mimic biosensory receptors, a biosensor selective for both molecular type and resonant frequency is developed. The sensing platform ensures significantly enhanced sensitivity and specificity by recognizing the intermolecular changes associated with serotonin-nanodisc binding and aqueous surrounding effects. The proposed biosensor can potentially provide an efficient tool for studying complex biochemical interactions, and find application in biomedical diagnostics and neuroscience research.

Exploring Neurotransmitter Dynamics Optical investigation of molecular dynamics occurring within the biomimetic human biosensor system, especially under water environment, has been regarded as a challenging area of study. Based on the great advantage of spectral capabilities of terahertz spectroscopic tools, a unique biosensing platform has been proposed assisted by nanodisc-hybridized nanoscale metasurfaces. The sensing capability was determined to enable the receptor-ligand interactions occurring at optical hotspots, where the terahertz field was strongly localized and greatly enhanced, and controlled by targeting specific frequency of the metasurface. More details can be found in article number 2504858 by Hyun Seok Song, Minah Seo, and co-workers.

The rapid growth of nanotechnology and spectroscopic techniques has accelerated the development of biosensors with high sensitivity and selectivity. Nanoscale metasurfaces can potentially overcome the limitations of conventional optical methods, such as low responsivity and molecular specificity. One promising approach for analyzing subtle biochemical changes that occur in complex biological phenomena is to use terahertz metasurfaces. Here, the aim is to develop a dual-selective terahertz nanodisc metasurface that enabled precise monitoring of neurotransmitter dynamics in a biomimetic environment. Utilizing functionalized terahertz metasurfaces with nanodisc that mimic biosensory receptors, a biosensor selective for both molecular type and resonant frequency is developed. The sensing platform ensures significantly enhanced sensitivity and specificity by recognizing the intermolecular changes associated with serotonin-nanodisc binding and aqueous surrounding effects. The proposed biosensor can potentially provide an efficient tool for studying complex biochemical interactions, and find application in biomedical diagnostics and neuroscience research.

Exploring Neurotransmitter Dynamics Optical investigation of molecular dynamics occurring within the biomimetic human biosensor system, especially under water environment, has been regarded as a challenging area of study. Based on the great advantage of spectral capabilities of terahertz spectroscopic tools, a unique biosensing platform has been proposed assisted by nanodisc-hybridized nanoscale metasurfaces. The sensing capability was determined to enable the receptor-ligand interactions occurring at optical hotspots, where the terahertz field was strongly localized and greatly enhanced, and controlled by targeting specific frequency of the metasurface. More details can be found in article number 2504858 by Hyun Seok Song, Minah Seo, and co-workers.

Abstract Achieving drastic color tuning in nanophotonic devices requires nanostructures optimized through a deep understanding of light‐matter interactions, including resonance wavelengths and their associated electric‐field distributions. This study rigorously investigates heat‐assisted nanoparticle rearrangement to achieve precise color tuning. A Fabry–Pérot (FP) etalon is proposed, comprising multi‐layered metal–dielectric–metal films, plasmonic nanoparticle assembly, a fluoropolymer dielectric, and a metal mirror layer, enabling nanoparticle‐behavior tracking at visible wavelengths. Through controlled experiments and simulations, the roles of physical elements in the FP etalon are investigated, particularly the optical cavity thickness and the filling fraction of the top layer. To enhance color variation through the dynamic behavior of nanoparticles during successive heating processes, a flowable polymer film is prepared as a dielectric layer, and color tunability is systematically examined. The investigation focuses on the heat‐assisted dynamic behavior of nanoparticles, including the submergence and coalescence of gold nanoparticles, along with the simultaneous shrinkage of the surrounding polymer film. Based on the results, laser‐mediated local color tuning via the photothermal effect of gold nanoparticles is performed for potential application as a color printing technique.

Recent advancements in wearable sweat sensors, which use standardized electrochemical and colorimetric mechanisms, offer holistic representation of health status for users. However, the constraints of standardized sweat sensors present ongoing challenges to realization of personalized health management. This study presents an electrocolorimetric (EC) platform that enables the reversible and multiple-time use of colorimetric data visualization using electrophoretic display (EPD). This platform represents the application of low-power EPD in epidermal sweat sensor, evaluated through CIELAB-based methodology which is the first systematic evaluation tool of wearable display performance. Moreover, our platform has been demonstrated in human exercise trials for its ability to detect the lactate threshold (LT). This digital colorimetric system has the potential to play a pivotal role by integrating various health monitoring biomarkers. While providing real-time, continuous, and adjustable range information with high sensitivity, this platform validates its extensive probability as a next-generation wearable epidermal sensor.