Background: The neurotrophic tyrosine receptor kinase (NTRK) fusion is an oncogenic driver found in various solid tumors.Larotrectinib is a highly selective TRK inhibitor and was approved for the treatment of advanced NTRK fusion-positive solid tumors by MFDS in 2020.However, the pivotal clinical trial includes only selected and fit patients with small proportion (less than 5%) of Asian ethnicity.

Objectives: To apply a healthy dietary program with reduced sodium intake, developed using data from the Korea National Health and Nutrition Examination Survey (KNHANES), focusing on the sodium intake level and eating patterns.Methods: The program was implemented using a living lab model, an open innovation ecosystem for user-centered problem-solving. Analysis of the KNHANES data revealed that older age groups had a low energy intake but a high sodium intake, particularly among those who frequently dined out. The program was designed to improve sodium-reduction literacy and enhance practical competency. Over four weeks, 40 participants tracked their dietary intake and worked with a clinical nutritionist through a process of diagnosis, experience, improvement, and expansion. A self-administered survey was conducted before and after the program to assess effectiveness.Results: Participants were four teenagers (10%), 26 in their twenties (65%), and 10 aged ≥ 30 years (25%), with eight males (20%) and 32 females (80%). Post-program analysis showed significant improvements in sodium-related nutrition knowledge (P < 0.01), with increased agreement on adopting low-sodium intake practices (e.g., interest in sodium content, choosing lower-sodium foods). Nutrient intake analysis showed a decrease in energy, carbohydrates, lipids, and proteins (P < 0.001), with sodium intake decreasing from 3,382.37 mg/d to 2,119.05 mg/d (P < 0.001).Conclusion: The community-based, living lab model for the sodium-reduction program effectively improved participant sodium-reduction literacy and practical competency, suggesting that step-by-step, autonomous learning, can reduce sodium intake and promote healthier eating habits.

This study demonstrated that a school-based smart health care service can effectively support adolescent health management by integrating personalized health data, gamification, and interactive tools. The usability evaluation revealed that students and parents prioritized sleep and physical activity tracking, while school health teachers emphasized the importance of monitoring physical activity. In addition, reward-based engagement strategies were identified as a promising approach to improve adolescent health behaviors. These findings suggest that leveraging digital health solutions tailored to adolescents' needs can contribute to establishing sustainable health habits from an early age.

In this large population-based study, simplified criteria incorporating a single question on widespread pain and easier-to-apply symptom cut-offs performed marginally better in identifying those with a diagnosis of FM.

Changes in metabolic health and obesity status significantly influence COVID-19 outcomes. Addressing obesity and promoting metabolic health are critical for mitigating the impact of COVID-19.