3D-Printed CNT-Reinforced Bioresorbable Vascular Scaffold with Enhanced Mechanical Stability and Integrated Wireless Pressure Sensor for Continuous Hemodynamic Monitoring
Nomin‐Erdene Oyunbaatar, Jinliang Wei, Lei Wang, Su‐Hwan Kim, Heonzoo Lee, Kyeongha Kwon, Yonggwan Won, Dong-Weon Lee
IF 9.1
ACS Sensors
Polymer-based bioresorbable vascular scaffolds (BVS) have garnered significant attention in biomedical applications. Among various BVS, polycaprolactone (PCL)-based scaffolds exhibit excellent biocompatibility, flexibility, chemical stability, and controlled degradation. However, their low radial strength limits practical applicability. Moreover, most reported BVS require periodic postimplantation monitoring to enable early detection of in-stent restenosis and thrombosis. To overcome these limitations, we fabricate a carbon nanotube (CNT)-reinforced PCL BVS using a 3D printing process, enabling patient-specific customization while significantly improving mechanical strength and durability. The proposed PCL/CNT-based stent not only serves as a structural scaffold but also facilitate real-time vascular pressure monitoring by integrating a wireless LC capacitive pressure sensor. The LC pressure sensor is microfabricated using microelectromechanical systems (MEMS) technology and exhibits highly stable resonance characteristics. A key innovation is the integration of a supporting micropillar within the capacitor cavity, which minimizes structural deformation and ensures a stable capacitance response. Mechanical testing demonstrates that PCL/CNT stents achieve significantly higher radial force (0.1 N/mm) compared to pristine PCL (0.013 N/mm). The wireless sensor exhibits high sensitivity (49 kHz/mmHg) with minimal capacitance variation (±5%). <i>In-vitro</i> studies in a phantom experiment confirm stable resonance frequency fluctuations that accurately correlate with hemodynamic changes. This smart stent integrates biodegradable nanocomposites, 3D printing, and wireless sensing, providing a noninvasive platform for restenosis and thrombosis monitoring. It marks a significant advancement in cardiovascular implants, paving the way for personalized and proactive patient care.
The PolyCraft Polymer–Metal Hybrid Smart Stent System: The Future of Cardiovascular Blood Pressure Management
Lei Wang, Nomin‐Erdene Oyunbaatar, Yun‐Jin Jeong, Heonzoo Lee, Yonggwan Won, In‐Seok Jeong, Mukhammad Kayumov, Francis O. Obiweluozor, Dong‐Su Kim, Dong‐Weon Lee
IF 19
Advanced Functional Materials
Abstract To address the complication of in‐stent restenosis that occurs with traditional stent treatments, this study proposes an innovative hybrid smart stent‐based medical system. This approach allows to overcome the limitations of existing bare metal or polymer‐based smart stents, which interfere with radio frequency signals, less deformability, or do not provide adequate radial support, respectively. The proposed hybrid stent, which uses a Co/Cr–polycaprolactone (PCL)–Co/Cr configuration connected by a unique dual inverted Y‐type connector for metal–polymer integration is integrated with a LC wireless pressure sensor fabricated through a semiconductor process. The fabricated hybrid stent made by laser machining and custom‐made 3D printing, offers excellent properties such as radial strength (0.125 N/mm) and flexibility (2 N mm 2 ) and provides intravascular information to the outside through the integrated sensor without signal degradation. After basic experiments using a phantom, animal experiments are conducted by combining the fabricated sensor with artificial blood vessel, and the results measured by the external antenna system are consistent with the results of a commercial reference sensor. The proposed wireless sensor‐based smart stents and artificial blood vessels aim to gather diverse patient health data for integration with artificial intelligence, laying the groundwork for next‐generation medical innovation.
3D-Printed CNT-Reinforced Bioresorbable Vascular Scaffold with Enhanced Mechanical Stability and Integrated Wireless Pressure Sensor for Continuous Hemodynamic Monitoring
Nomin‐Erdene Oyunbaatar, Jinliang Wei, Lei Wang, Su‐Hwan Kim, Heonzoo Lee, Kyeongha Kwon, Yonggwan Won, Dong-Weon Lee
IF 9.1
ACS Sensors
Polymer-based bioresorbable vascular scaffolds (BVS) have garnered significant attention in biomedical applications. Among various BVS, polycaprolactone (PCL)-based scaffolds exhibit excellent biocompatibility, flexibility, chemical stability, and controlled degradation. However, their low radial strength limits practical applicability. Moreover, most reported BVS require periodic postimplantation monitoring to enable early detection of in-stent restenosis and thrombosis. To overcome these limitations, we fabricate a carbon nanotube (CNT)-reinforced PCL BVS using a 3D printing process, enabling patient-specific customization while significantly improving mechanical strength and durability. The proposed PCL/CNT-based stent not only serves as a structural scaffold but also facilitate real-time vascular pressure monitoring by integrating a wireless LC capacitive pressure sensor. The LC pressure sensor is microfabricated using microelectromechanical systems (MEMS) technology and exhibits highly stable resonance characteristics. A key innovation is the integration of a supporting micropillar within the capacitor cavity, which minimizes structural deformation and ensures a stable capacitance response. Mechanical testing demonstrates that PCL/CNT stents achieve significantly higher radial force (0.1 N/mm) compared to pristine PCL (0.013 N/mm). The wireless sensor exhibits high sensitivity (49 kHz/mmHg) with minimal capacitance variation (±5%). <i>In-vitro</i> studies in a phantom experiment confirm stable resonance frequency fluctuations that accurately correlate with hemodynamic changes. This smart stent integrates biodegradable nanocomposites, 3D printing, and wireless sensing, providing a noninvasive platform for restenosis and thrombosis monitoring. It marks a significant advancement in cardiovascular implants, paving the way for personalized and proactive patient care.
The PolyCraft Polymer–Metal Hybrid Smart Stent System: The Future of Cardiovascular Blood Pressure Management
Lei Wang, Nomin‐Erdene Oyunbaatar, Yun‐Jin Jeong, Heonzoo Lee, Yonggwan Won, In‐Seok Jeong, Mukhammad Kayumov, Francis O. Obiweluozor, Dong‐Su Kim, Dong‐Weon Lee
IF 19
Advanced Functional Materials
Abstract To address the complication of in‐stent restenosis that occurs with traditional stent treatments, this study proposes an innovative hybrid smart stent‐based medical system. This approach allows to overcome the limitations of existing bare metal or polymer‐based smart stents, which interfere with radio frequency signals, less deformability, or do not provide adequate radial support, respectively. The proposed hybrid stent, which uses a Co/Cr–polycaprolactone (PCL)–Co/Cr configuration connected by a unique dual inverted Y‐type connector for metal–polymer integration is integrated with a LC wireless pressure sensor fabricated through a semiconductor process. The fabricated hybrid stent made by laser machining and custom‐made 3D printing, offers excellent properties such as radial strength (0.125 N/mm) and flexibility (2 N mm 2 ) and provides intravascular information to the outside through the integrated sensor without signal degradation. After basic experiments using a phantom, animal experiments are conducted by combining the fabricated sensor with artificial blood vessel, and the results measured by the external antenna system are consistent with the results of a commercial reference sensor. The proposed wireless sensor‐based smart stents and artificial blood vessels aim to gather diverse patient health data for integration with artificial intelligence, laying the groundwork for next‐generation medical innovation.
Ultra-Sensitive Wireless Pressure Sensor for Real-Time Cardiovascular Restenosis Monitoring in Smart Stents
Lei Wang, Nomin‐Erdene Oyunbaatar, Dong‐Su Kim, Jinliang Wei, Yun‐Jin Jeong, Heonzoo Lee, Su-Hwan Kimv, Yonggwan Won, Kyeongha Kwon, In‐Seok Jeong, Dong‐Weon Lee
In this paper, we introduce an innovative high-sensitivity wireless LC pressure sensor that is carefully designed for integration into biodegradable polymer stents, providing a remarkable improvement in restenosis detection. The key to this breakthrough is a significant increase in the cavity volume of the capacitive pressure sensor in the design. This design optimization improves the sensor sensitivity by a factor of 7. This improved sensitivity has been consistently demonstrated through our comprehensive performance evaluation (phantom and animal experiment) in air and liquid conditions while confirming the robustness and reliability of the sensor in various environments. The smart stent proposed in this study is the first to demonstrate practical medical potential.
A novel approach for estimating initial sound level for speech reception threshold test
Heonzoo Lee, Rayoung Park, Sejin Kim, Hyong‐Ho Cho, Yonggwan Won
IF 1.8
Technology and Health Care
This outcome substantiates that our approach can reduce the repetitions for finding the final SRT, and, as the result, the hearing test time can be reduced.
A Fast and Simple Method for Sleep Breathing Cycle Segmentation in Time Domain
Ra‐Young Park, H. B. Lee, Tan Loc Nguyen, Sejin Kim, Yonggwan Won
An automatic sleep respiratory cycle segmentation method in time-domain is introduced. Unlike the methods using spectral analysis that require high computational process such as Fourier transform, our approach uses a nonoverlapping window for simple computation in time domain, which is suitable for low power computing systems. Typical sleep breathing sound files over 6-hour length were used to evaluate our method, and the experimental results showed that our method demonstrated the accuracy over 95% and possible improvement with further investigation on parameter optimization for the steps by close examination of the signal characteristics.
Enhancing Flexibility of Smart Bioresorbable Vascular Scaffolds Through 3d Printing Using Polycaprolactone and Polylactic Acid
Jinliang Wei, Nomin‐Erdene Oyunbaatar, Yun-Jin Jeong, Jong Sung Park, Su‐Hwan Kim, Kyeongha Kwon, Heonzoo Lee, Yonggwan Won, Dong-Su Kim, Dong‐Weon Lee
Comparison of laser-induced breakdown spectroscopy (LIBS) and ICP analysis results for measuring Pb and Zn in soil
Hyeon Yang, Young-Tae Jo, Jihyo Chong, Yonggwan Won, Jeong‐Hun Park
IF 1.5
Soil Research
Context Laser-induced breakdown spectroscopy (LIBS) is a rapid, multielement analytical technique. It is particularly suitable for the qualitative and quantitative analyses of heavy metals in solid samples. Aims To validate the technique, the LIBS data were compared with the data obtained via conventional inductively coupled plasma (ICP) spectroscopy for the same soil samples. Methods In this study, standard and unknown soil samples from contaminated areas were prepared and fixed to an adhesive tape for LIBS analysis. The soils were also digested with acids for ICP analysis. The emission intensity of one selected line for each of the two analytes, i.e. lead (Pb) and zinc (Zn), was normalised to the background signal and plotted as a function of the concentration values previously determined via ICP analysis. Key results The data demonstrated good linearity for the calibration lines drawn, and the correlation between the ICP and LIBS data was confirmed by the satisfactory agreement between the corresponding values. Conclusions The concentration coefficient of determination (R2) between LIBS and ICP-aqua regia digestion analysis or ICP-total digestion analysis were &gt;0.86 and &gt;0.89 for Pb and Zn, respectively. The total analysis time for the LIBS method was 310 min, which was 54.40% shorter than that for the ICP method (680 min). Implications Consequently, LIBS can be used to measure Pb and Zn in soils without any chemical preparation.